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According to the observations from Kadowaki et al. ( 5 ), the PorX/PorY system upregulates transcription of the sigP gene (i.e., PGN_0274) that encodes an extracytoplasmic function sigma factor, σ P, and then σ P mediates transcriptional activation of the por genes by binding to their promoters.

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PorX/PorY is a two-component system (TCS) of Porphyromonas gingivalis that governs transcription of numerous genes including those encoding a type IX secretion system (T9SS) for gingipain ...